000			02050na a2200229 4500
003			PC8661
005			20180417114645.0
008			150701b2011 xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91207 _aCastellano Tortajada, Gregorio _eAparato Digestivo
245	0	0	_aPathogenesis of occult chronic hepatitis B virus infection _h[artículo]
260			_bWorld Journal of Gastroenterology, _c2011.
300			_a17(12):1543-1548.
500			_aFormato Vancouver: De la Fuente RA, Gutiérrez ML, Garcia-Samaniego J, Fernández-Rodriguez C, Lledó JL, Castellano G. Pathogenesis of occult chronic hepatitis B virus infection. World J Gastroenterol. 2011;17(12):1543-8.
501			_aPMID: 21472118
504			_aContiene 59 referencias.
520			_aOccult hepatitis B infection (OBI) is characterized by hepatitis B virus (HBV) DNA in serum in the absence of hepatitis B surface antigen (HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns. Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays; but more frequently it is due to a strong suppression of viral replication and gene expression. OBI is an entity with world-wide diffusion. The failure to detect HBsAg, despite the persistence of the viral DNA, is due in most cases to the strong suppression of viral replication and gene expression that characterizes this "occult" HBV infection; although the mechanisms responsible for suppression of HBV are not well understood. The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection. Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma.
710			_9273 _aServicio de Medicina del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc8661.pdf _ySolicitar documento
942			_2ddc _cART _n0
999			_c8661 _d8661