000 | 02216na a2200253 4500 | ||
---|---|---|---|
003 | PC9733 | ||
005 | 20210625062810.0 | ||
008 | 130622s2011 xxx||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_91016 _aDelgado Vázquez, Rafael _eMicrobiología y Parasitología |
||
100 |
_aLuczkowiak, Joanna _91611 _eMicrobiología y Parasitología |
||
245 | 0 | 0 |
_aPseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection _h[artículo] |
260 |
_bBioconjugate Chemistry, _c2011. |
||
300 | _a22(7):1354-1365. | ||
500 | _aFormato Vancouver: Luczkowiak J, Sattin S, Sutkevičiūtė I, Reina JJ, Sánchez-Navarro M, Thépaut M, et al. Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection. Bioconjug Chem. 2011;22(7):1354-65. | ||
501 | _aPMID:21650462 | ||
504 | _aContiene 44 referencias. | ||
520 | _aThe development of compounds with strong affinity for the receptor DC-SIGN is a topic of remarkable interest due to the role that this lectin plays in several pathogen infection processes and in the modulation of the immune response. DC-SIGN recognizes mannosylated and fucosylated oligosaccharides in a multivalent manner. Therefore, multivalent carbohydrate systems are required to interact in an efficient manner with this receptor and compete with the natural ligands. We have previously demonstrated that linear pseudodi- and pseudotrisaccharides are adequate ligands for DC-SIGN. In this work, we show that multivalent presentations of these glycomimetics based on polyester dendrons and dendrimers lead to very potent inhibitors (in the nanomolar range) of cell infection by Ebola pseudotyped viral particles by blocking DC-SIGN receptor. Furthermore, SPR model experiments confirm that the described multivalent glycomimetic compounds compete in a very efficient manner with polymannosylated ligands for binding to DC-SIGN. | ||
710 |
_981 _aServicio de Microbiología y Parasitología |
||
710 |
_9625 _aInstituto de Investigación imas12 |
||
856 |
_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/9/pc9733.pdf _ySolicitar documento |
||
942 |
_2ddc _cART _n0 |
||
999 |
_c9733 _d9733 |